MyBody-X angle on MTHFR Ernährung

The MTHFR gene encodes methylenetetrahydrofolate reductase, a key enzyme in folate and homocysteine metabolism. Common variants such as rs1801133 (C677T) and rs1801131 (A1298C) can reduce enzyme activity, associated with elevated homocysteine levels. From a nutritional perspective, increased intake of bioactive folate (e.g., 5-methyltetrahydrofolate) along with vitamins B12, B6, and betaine is often suggested. However, the evidence is mixed: some randomized controlled trials show that methylfolate supplementation lowers homocysteine in carriers of risk variants, but long-term outcome data (e.g., cardiovascular events) are lacking. Guidelines do not recommend universal MTHFR screening. A MyBody-X genetic test can determine genotype, but interpretation requires clinical context. A balanced diet rich in natural folate (leafy greens, legumes) is advisable for everyone. Caveat: Do not self-diagnose or self-treat without medical supervision.