What role does BDNF play in Sport?

BDNF (Brain-Derived Neurotrophic Factor) is a protein crucial for neuronal survival, growth, and synaptic plasticity. In sports, physical activity—especially aerobic endurance exercise—increases BDNF levels in the brain and bloodstream, which is linked to improved cognitive function, mood, and potential neuroprotection. The BDNF Val66Met polymorphism (rs6265) reduces activity-dependent BDNF secretion, which might affect training adaptations. However, evidence for genotype-specific exercise or supplement recommendations is weak and inconsistent. A healthy lifestyle with regular exercise benefits everyone regardless of genotype. Supplements like omega-3 fatty acids or curcumin are sometimes suggested but lack strong evidence. Caution: BDNF is just one piece of a complex puzzle; overemphasis on a single gene or biomarker can lead to misleading conclusions. Evidence grade: human-moderate (observational studies, small trials). No specific dietary or training changes are warranted based solely on BDNF genetics.