How are LDL and Wechseljahre related?

During menopause (Wechseljahre), estrogen levels decline, which often leads to an increase in LDL cholesterol. Estrogen enhances LDL receptor activity in the liver, promoting clearance of LDL from the blood. After menopause, this receptor activity decreases, causing LDL to rise while HDL may drop or remain stable. This shift negatively affects women's cardiovascular risk profile. However, the effect varies individually and is modulated by genetics, diet, exercise, and lifestyle. The provided context does not contain specific studies on LDL and menopause; this answer is based on general medical knowledge. Therefore, lipid profiles should be monitored regularly during the menopausal transition. Dietary changes or statin therapy may be considered for elevated levels, but always under medical guidance. The evidence is rated as human-moderate because the association is well-established, though not directly supported by the given sources.