The LCT gene encodes lactase, which breaks down lactose. While lactose intolerance may lead to reduced dairy intake and thus lower calorie consumption, there is no strong evidence that LCT variants directly cause or significantly aid weight loss. Direct-to-consumer DNA tests often overstate the role of single genes like LCT in metabolism. Weight loss is multifactorial, relying on overall energy balance, diet quality, and physical activity. If you are lactose intolerant, avoiding dairy might reduce bloating or discomfort, but this is not a proven weight-loss intervention. Evidence: weak, mechanistic/marketing. No clinical guidelines support using LCT genotype for weight management.
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