Evidence check: hsCRP in the context of fatigue

High-sensitivity C-reactive protein (hsCRP) is a non-specific marker of systemic inflammation. Elevated levels can be associated with fatigue in conditions like chronic inflammation, autoimmune disorders, or metabolic syndrome. However, hsCRP is not a specific test for fatigue; many individuals with fatigue have normal hsCRP, and elevated hsCRP can occur without fatigue. The evidence linking hsCRP directly to fatigue is moderate, based on observational studies. While hsCRP can be a useful adjunct in a clinical workup, it is insufficient as a standalone biomarker for fatigue. Consumer tests that market hsCRP as a 'fatigue' or 'energy' marker often overstate its clinical utility. Important: elevated hsCRP warrants medical evaluation for underlying causes such as cardiovascular risk or chronic inflammatory conditions. Interpretation must consider age, BMI, smoking, and acute infections. Always consult a physician before making health decisions based on hsCRP results.