Triglycerides are blood fats; elevated levels (hypertriglyceridemia) are associated with increased risk of cardiovascular disease – a major contributor to reduced lifespan. However, the direct link between triglycerides and longevity is complex and not causally established. Observational studies show that very high triglycerides (>500 mg/dL) raise the risk of pancreatitis and cardiovascular events, potentially shortening lifespan. Conversely, low triglycerides often reflect better metabolic health, but are not a guarantee of longevity. Genetic factors (e.g., variants in APOA5, LPL) influence triglyceride regulation, but individual gene effects are small. Lifestyle factors – such as diet (low sugar, omega-3 fatty acids), exercise, and weight management – have a much larger impact on triglyceride levels than genetics. A DNA test can indicate genetic predispositions, but its clinical relevance for individual longevity is limited. Regular blood lipid measurements and a healthy lifestyle are more actionable. Evidence: human-moderate (observational studies, no strong interventional data on longevity).
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