MTHFR is a gene that codes for an enzyme involved in folate metabolism. Common variants like C677T (rs1801133) reduce enzyme activity modestly. Most people with a variant do not develop health issues because dietary folate intake is usually sufficient. Supplementation with methylfolate is only medically indicated in rare cases, such as elevated homocysteine. Many direct-to-consumer tests exaggerate the importance of MTHFR variants for nutrition. The evidence for a general dietary adjustment or special supplements is weak. Instead, a balanced diet rich in natural folate from leafy greens, legumes, and whole grains is recommended. A blood test for homocysteine and folate can provide clarity if symptoms are present. Be cautious of overblown claims: most MTHFR variants are benign and do not require a special diet.
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