How are Östradiol and Wechseljahre related?

The relationship between estradiol and menopause is well-established in medical science, but the provided context does not address it. Estradiol is the predominant estrogen during reproductive years, produced mainly by the ovaries. During the menopausal transition (perimenopause), estradiol levels decline, causing irregular cycles and symptoms like hot flashes, night sweats, vaginal dryness, and mood changes. After menopause, estradiol remains low, increasing long-term risks for osteoporosis and cardiovascular disease. Hormone replacement therapy (HRT) with estradiol can effectively manage symptoms, but its use requires careful risk-benefit assessment (e.g., thrombosis, breast cancer risk). The evidence is human-strong, based on decades of clinical research and guidelines. Since the context lacks specific studies or markers, no sources are cited. Caveat: direct-to-consumer estradiol tests are not validated for menopause management and should not replace clinical evaluation.