What role does Östradiol play in gut health?

The provided context does not contain information on the role of estradiol in gut health. Generally, estradiol is known to influence gut barrier integrity, microbiota composition, and inflammation via estrogen receptors in the intestinal epithelium. However, evidence is largely from animal models and observational human studies; no direct clinical or genetic data from the given sources. Thus, the evidence is weak and mechanistic. Consumer DNA or lab tests claiming to link estradiol to gut health are not supported by the context. Caveat: Do not alter diet or hormone therapy based solely on such tests.