CYP1A2 is a liver enzyme primarily responsible for metabolizing caffeine and certain drugs. Genetic variants (e.g., rs762551) determine whether someone is a fast or slow caffeine metabolizer. For weight loss, this may matter because caffeine can temporarily increase energy expenditure and fat oxidation. However, the evidence is mixed: some studies suggest fast metabolizers benefit more from caffeine, while others find no clear link. The effects are modest and overshadowed by diet, exercise, and lifestyle. MyBody-X may include CYP1A2 in its DNA test, but its predictive power for weight loss is limited. A genetic test alone does not replace personalized nutrition advice. Caveat: caffeine can disrupt sleep and raise cortisol in sensitive individuals, potentially hindering long-term weight management.
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