What role does CLOCK play in menopause?

CLOCK genes are core regulators of circadian rhythms. During menopause, hormonal changes (e.g., estrogen decline) can disrupt sleep-wake cycles, which may theoretically involve CLOCK variants. However, the provided context contains no specific studies or data linking CLOCK to menopause. The evidence is therefore classified as unclear. There is currently no clinical relevance; DNA tests on this topic are purely exploratory. For sleep issues during menopause, medical advice should be sought.