Myths vs facts: tTG IgA and fatigue

The provided context does not directly address tTG IgA and fatigue. In clinical practice, tTG IgA is a specific serological marker for celiac disease. Fatigue can be a symptom of untreated celiac disease due to malabsorption and systemic inflammation. A common myth is that a positive tTG IgA test always causes fatigue, or that fatigue alone warrants celiac testing. The fact is that fatigue is highly non-specific and can result from many conditions (e.g., iron deficiency, sleep disorders, stress). A positive tTG IgA requires confirmation via duodenal biopsy. Without celiac disease, the link to fatigue is not established. The evidence for the association is strong in medical guidelines, but since the context lacks supporting sources, the evidence rating is marked as unclear. Caveat: tTG IgA is not a general fatigue test; self-diagnosis is not recommended.