How are FUT2 and Langlebigkeit related?

The relationship between FUT2 (fucosyltransferase 2) and longevity is indirect and largely mechanistic. FUT2 determines secretor status: individuals with a functional FUT2 gene (secretors) express ABO blood group antigens in body fluids, which shapes gut microbiota composition. Secretors tend to harbor more Bifidobacteria, linked to better gut health and immune function. Additionally, FUT2 influences vitamin B12 absorption; non-secretors have higher risk of B12 deficiency, which can elevate homocysteine and increase cardiovascular risk, potentially shortening lifespan. However, direct evidence linking FUT2 to human longevity is lacking. Most data come from association studies and mechanistic pathways. Consumer DNA tests (e.g., MyBody-X) can report FUT2 variants, but the clinical utility for longevity prediction is unproven. Practical advice: focus on diet, B12 monitoring, and gut health rather than relying solely on genetic markers. Evidence grade: mechanistic/unclear.