Risks and limits of Longevity Genetik

Longevity genetics is an emerging field with clear limitations and risks. MyBody-X DNA tests analyze SNPs such as FOXO3 (rs2802292), which GWAS associate with platelet width, not directly with longevity. Other markers like NRF2 (rs6721961) relate to antioxidant response but have small effect sizes. The evidence is mostly mechanistic or from GWAS, not clinical trials. Furthermore, in Germany, the Genetic Diagnostics Act (GenDG) prohibits medical claims without physician oversight. These tests are marketed as lifestyle products, not medical diagnostics. A key risk is overinterpretation: a single SNP often explains less than 1% of lifespan variance. Interactions with environment (diet, exercise) are complex and unpredictable. Consumers should understand that longevity is polygenic and multifactorial – a single genetic test cannot provide a reliable prognosis. Limitations include lack of clinical validation, low predictive power, and legal restrictions. For medical concerns, consult a doctor.