A high AMH (anti-Müllerian hormone) level typically indicates a high ovarian reserve, which is common in younger women. However, markedly elevated AMH is also a hallmark of polycystic ovary syndrome (PCOS), where numerous small follicles produce excess AMH. Interpretation is strongly age-dependent: in women over 35, a high AMH is less common and warrants endocrinological evaluation. Importantly, AMH reflects egg quantity, not quality, and does not predict fertility or pregnancy success. Laboratory variability exists (e.g., hormonal contraceptive use can lower AMH). The evidence base is clinical practice and large cohort studies, not RCTs. A high AMH alone is not diagnostic; it must be interpreted alongside cycle history, other hormones, and ultrasound. For those trying to conceive or with irregular cycles, medical consultation is advised. Caution: direct-to-consumer AMH tests may lack validated reference ranges, leading to misinterpretation.
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