hsCRP (high-sensitivity C-reactive protein) is an inflammatory marker that plays a role in fertility by indicating low-grade chronic inflammation. Elevated hsCRP has been associated with female fertility issues such as endometriosis, polycystic ovary syndrome (PCOS), and diminished ovarian reserve. In men, higher hsCRP may correlate with reduced sperm quality and testicular dysfunction. However, hsCRP is not a direct fertility test; it is a non-specific marker influenced by many factors (obesity, smoking, infections). The evidence is based on observational studies, not randomized controlled trials. An elevated hsCRP alone does not diagnose infertility but can serve as a screening tool for underlying inflammatory conditions. If hsCRP is high, further medical evaluation (e.g., gynecological or andrological workup) is recommended. Consumer hsCRP tests provide useful information but are insufficient for a comprehensive fertility assessment.
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