What to watch with HLA-DQ2 and Fruchtbarkeit?

HLA-DQ2 is a genetic risk factor for celiac disease, but not a direct marker for fertility issues. However, undiagnosed or untreated celiac disease can contribute to fertility problems in both women and men. Studies indicate that a gluten-free diet can improve fertility outcomes in celiac patients. Important: HLA-DQ2 alone is not diagnostic; about 30 % of the population carry it, but only a minority develop celiac disease. A positive result should prompt medical evaluation (e.g., antibody testing, duodenal biopsy), especially if there is unexplained infertility or other symptoms. Without a celiac diagnosis, no specific dietary changes are warranted. Evidence is based on observational studies, not RCTs. Be cautious of exaggerated claims from direct-to-consumer genetic tests suggesting a direct link.