hsCRP is a marker of systemic inflammation. Elevated levels may be associated with reduced fertility in both men and women, e.g., affecting ovulation, sperm quality, and implantation. However, hsCRP is non-specific; it can rise due to infections, obesity, smoking, or chronic conditions. A single high reading does not diagnose infertility. Lifestyle factors like diet, exercise, and weight management can lower hsCRP. Evidence is moderate: observational studies show correlation but not causation. Do not interpret hsCRP alone; use it as part of a broader fertility workup. Consider testing for underlying causes if hsCRP is persistently high. Caution: a high hsCRP may also indicate acute infection – address that first before focusing on fertility.
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