Evidence check: Triglyceride senken in the context of Wechseljahre

Lowering triglycerides during menopause is clinically relevant because declining estrogen levels can worsen lipid profiles. Genetic testing (e.g., PPARA, FTO variants) offers only weak to moderate predictive value for triglyceride response; effect sizes are small. Stronger evidence supports lifestyle interventions: a Mediterranean diet rich in omega-3 fatty acids (fish, flaxseed), regular aerobic exercise, and weight management. Omega-3 supplements (EPA/DHA) can reduce triglycerides by 15–30%, but dosing should be individualized and discussed with a physician. DNA tests may hint at metabolic tendencies but are not sufficient for personalized dietary prescriptions. Importantly, very high triglycerides (>500 mg/dL) require medical evaluation due to pancreatitis risk. Overall, the evidence for triglyceride reduction in menopause is human-moderate, based on clinical trials and observational studies, not on robust genetic associations.