What role does LCT play in Wechseljahre?

The role of LCT (lactase persistence) in menopause is not directly supported by scientific evidence. LCT encodes the enzyme lactase, which breaks down lactose in dairy. The common variant rs4988235 determines adult lactose tolerance. During menopause, estrogen decline can alter gut microbiota and intestinal transit, potentially affecting lactose digestion indirectly. However, no robust studies link LCT variants to menopausal symptoms like hot flashes, mood changes, or bone loss. Evidence is therefore 'unclear'. Some women report increased dairy sensitivity during menopause, but this is likely multifactorial (hormonal, gut changes) rather than genetic. A DNA test for LCT can indicate lifelong lactose tolerance, but it does not predict menopausal symptoms. Consumers should be cautious of claims that LCT directly influences menopause – such assertions lack clinical validation. If you experience digestive issues during menopause, consult a healthcare provider rather than relying solely on genetic results.