What role does Progesteron play in Müdigkeit?

Progesterone can induce fatigue through its metabolite allopregnanolone, which enhances GABA-A receptor activity, producing sedative effects. Elevated progesterone levels during the luteal phase or pregnancy are consistently linked to increased sleepiness and tiredness in human studies. The evidence is human-strong, supported by clinical and neurobiological research. However, fatigue is multifactorial; other causes like stress, poor sleep, or thyroid issues must be considered. Direct-to-consumer genetic tests for progesterone-related variants currently lack clinical utility for diagnosing fatigue. If tiredness is persistent or severe, a medical evaluation is warranted. Hormonal supplements should only be used under professional guidance.