What role does Stuhlprobe play in Müdigkeit?

A stool sample (Stuhlprobe) is used to analyze the gut microbiome. Research suggests that the gut microbiota can influence fatigue through the gut-brain axis, inflammation, and neurotransmitter production (e.g., serotonin). Altered microbiome compositions have been observed in conditions like chronic fatigue syndrome (ME/CFS). However, the evidence for a direct causal role of stool analysis in fatigue is still limited and mostly mechanistic or observational. Lifestyle factors such as diet, stress, sleep, and exercise are stronger determinants of energy levels. Consumer microbiome tests often overstate the clinical relevance of specific bacterial strains. A stool sample may provide clues but cannot diagnose or pinpoint a single cause of fatigue. Interpretation should be cautious and combined with other biomarkers. Evidence: mixed; beware of overblown claims.