Is SHBG useful for Fruchtbarkeit?

SHBG (sex hormone-binding globulin) is a carrier protein for testosterone and estradiol. Low SHBG is often linked to insulin resistance, metabolic syndrome, and PCOS – all factors that can impair fertility. However, SHBG is not a direct fertility marker. The clinical utility of isolated SHBG testing for fertility prognosis is limited because individual variability is high and lifestyle factors (diet, exercise, weight) have a stronger influence. When combined with other hormone parameters (e.g., LH, FSH, testosterone, estradiol), SHBG can provide clues to underlying disorders. Evidence: moderate human studies, but no RCTs proving benefit of SHBG testing alone for fertility. Caveat: not a routine recommendation without medical evaluation.