What role does BDNF play in Abnehmen?

BDNF (Brain-Derived Neurotrophic Factor) is a protein crucial for neuronal plasticity and survival, especially in the brain. It also plays a key role in energy homeostasis by influencing appetite and satiety via the hypothalamus. Low BDNF levels have been linked to obesity and increased food intake in observational studies. However, direct evidence that BDNF variants or levels predict weight loss success in humans is limited. Genome-wide association studies (GWAS) have identified BDNF SNPs (e.g., rs6265) associated with BMI, but effect sizes are small and population-specific. Consumer genetic tests for BDNF are not clinically validated for weight management. Lifestyle interventions (diet, exercise) remain the primary drivers of weight loss. In summary, BDNF is a relevant neurotrophic factor in energy balance, but its role as a practical weight-loss marker is not supported by strong evidence.