Is ApoB useful for allergy?

ApoB (Apolipoprotein B) is a core component of LDL and VLDL particles and is primarily used for cardiovascular risk assessment. In allergology, ApoB has no established role. Allergic reactions are mainly mediated by IgE, mast cells, eosinophils, and cytokines such as IL-4, IL-5, and IL-13. There are isolated mechanistic hints that oxidized lipoproteins or ApoB-containing particles might influence inflammatory processes, but this is not a clinically relevant biomarker for allergies. The evidence for a direct link is weak and based on preclinical studies, not validated diagnostic applications. Therefore, an ApoB test is not indicated for allergy diagnostics. If someone suspects an allergy, specific IgE tests or skin prick tests are more appropriate. Measuring ApoB can still be useful for cardiovascular risk assessment, especially in metabolic conditions associated with chronic inflammation. Overall, the utility of ApoB for allergy is minimal.