Evidence check: IgE Allergietest in the context of stress

The IgE allergy test measures specific IgE antibodies to allergens and is a validated method for diagnosing type I immediate hypersensitivity (e.g., pollen, foods). Stress can influence immune function – some evidence suggests chronic stress may modulate IgE production or exacerbate allergic symptoms. However, the evidence is moderate and insufficient to recommend IgE tests as stress markers. Test results primarily indicate allergic sensitization, not stress load. Clinically, a combination of history, provocation tests, and IgE measurement is more relevant. Caution: IgG tests for food intolerances are scientifically controversial and should not be equated with IgE tests. For stress-related complaints, psychosocial factors and possibly cortisol measurements should be prioritized. Evidence: human-moderate (stress-IgE association), practice (IgE test validity).