What to watch with Pharmakogenetik Medicheck and Schlaf?

The Medicheck primarily analyzes drug metabolism genes (e.g., CYP2C9, CYP2C19, CYP2D6). For sleep, relevant medications include zolpidem, melatonin, and antihistamines – their breakdown can be affected by these variants. However, effects are moderate, and a genetic test does not replace medical sleep diagnostics. Sleep-wake genes (e.g., CLOCK, PER) are usually not included in standard panels. Evidence for personalized dosing of sleep aids is limited; CPIC guidelines exist only for a few substances. Beware of overinterpretation: a 'slow' metabolizer status does not automatically mean a drug is ineffective or dangerous – clinical decisions should always be made by a physician. Additionally, interactions with other medications (e.g., antidepressants) can affect sleep. Bottom line: The test provides clues, not a sleep diagnosis. Discuss results with a pharmacist or doctor before changing any sleep medication.