Leaky Gut Test: which blood markers matter?

The question of which blood markers matter for a 'leaky gut' test is complex, as the concept of increased intestinal permeability remains scientifically debated. Research often measures markers like zonulin (a tight junction regulator), lipopolysaccharides (LPS), or antibodies against actomyosin and occludin. However, no single blood marker is clinically validated as a diagnostic standard for leaky gut. Many commercial tests combine these markers without sufficient evidence for their predictive value. The provided context does not contain specific data on leaky gut blood markers but highlights general issues with IgG food intolerance tests and DNA-based claims. Therefore, caution is warranted: a positive result should not be the sole basis for dietary or therapeutic interventions. If you suspect intestinal permeability, consult a gastroenterologist who can use established methods like the lactulose/mannitol test or endoscopy.