What role does HLA-DQ2 play in sleep?

HLA-DQ2 is an HLA class II molecule primarily associated with celiac disease. There is no direct causal evidence linking HLA-DQ2 to sleep regulation. Indirect connections exist: individuals with celiac disease may experience sleep disturbances due to inflammation or nutritional deficiencies, but this is not specific to HLA-DQ2. The immune system, including HLA molecules, can influence sleep via cytokine signaling, but robust human studies demonstrating a direct role for HLA-DQ2 in sleep are lacking. Evidence is therefore mechanistic and unclear. Genetic testing for HLA-DQ2 does not provide actionable information about sleep. Clinically relevant sleep issues should be evaluated by a physician.