Can FUT2 help with longevity?

Whether the FUT2 gene can contribute to longevity is not yet scientifically settled. FUT2 encodes a fucosyltransferase that determines the secretion of ABO blood group antigens into body fluids. Variants (e.g., rs601338) influence gut microbiota composition and vitamin B12 absorption. Some studies suggest links to immune function and chronic inflammation—factors that could theoretically affect lifespan. However, robust longitudinal data demonstrating a direct causal effect on human longevity are lacking. The evidence is currently mostly mechanistic or from GWAS with small effect sizes. Moreover, the genetic information is not clinically actionable: adjusting diet or supplementation based solely on FUT2 status is not evidence-based. For consumers of DNA tests, FUT2 results should be considered exploratory and not used for major health decisions. A healthy lifestyle with adequate B12 intake (e.g., supplements for vegans) is universally recommended, regardless of genotype.