Can BDNF help with weight loss?

BDNF (Brain-Derived Neurotrophic Factor) is primarily known for its role in neuroplasticity, but it also influences energy metabolism and appetite regulation. Some animal and human studies suggest that low BDNF levels are linked to obesity, and that increasing BDNF—through exercise or certain supplements—might support weight loss. However, the evidence is not strong enough to recommend BDNF as a standalone weight loss aid. Its effects are indirect and heavily modulated by lifestyle factors like physical activity and diet. Direct BDNF supplementation is not established, and bioavailability is questionable. Caveat: No clinical guidelines endorse BDNF supplements for weight loss. A DNA test for BDNF variants (e.g., rs6265) may indicate individual differences, but effect sizes are small. Evidence: human-moderate.