Myths vs facts: IgE and Wechseljahre

The relationship between IgE and menopause is not well established. IgE is primarily involved in allergic responses and parasitic infections. During menopause, declining estrogen levels may modulate immune function, and some observational studies have reported slight increases in total IgE postmenopause, but results are inconsistent. A common myth is that IgE directly causes menopausal symptoms like hot flashes – there is no evidence for this. A fact is that IgE levels are highly individual and influenced by genetics, allergies, and environment. Without allergic symptoms, an elevated IgE in menopause is not clinically actionable. Current evidence is limited to small observational studies; no large-scale trials exist. Therefore, no firm conclusions can be drawn. Evidence grade: human-observational/unclear.