What to watch with VKORC1 and fertility?

VKORC1 is primarily known for its role in vitamin K metabolism and warfarin sensitivity, not directly for fertility. Some mechanistic hypotheses suggest that vitamin K influences coagulation, bone health, and possibly placental development, but robust human studies linking VKORC1 variants to fertility outcomes are lacking. If you have a VKORC1 result from a consumer DNA test, be cautious: the evidence is weak and speculative. Fertility is multifactorial, and genetic variants in VKORC1 are unlikely to be a major contributor. For anyone trying to conceive, focus on clinically validated factors like hormonal balance, cycle regularity, and lifestyle. A VKORC1 test is not a fertility diagnostic.