BDNF (Brain-Derived Neurotrophic Factor) is a protein crucial for neuronal survival and plasticity. In the context of longevity, BDNF is discussed as a potential biomarker for healthy aging, as it is associated with cognitive function, neurogenesis, and metabolic health. Studies indicate that higher BDNF levels correlate with a lower incidence of dementia and cardiovascular diseases. However, evidence for a direct causal role in extending maximum human lifespan is limited. Most data come from animal models or epidemiological studies. Exercise, certain diets (e.g., Mediterranean diet), and caloric restriction can increase BDNF. A direct benefit for longevity in terms of lifespan extension is not clearly proven, but BDNF appears to contribute to healthspan. The provided context does not contain specific data on BDNF, so this answer is based on general scientific knowledge.
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