What role does CRP Entzündung play in longevity?

CRP (C-reactive protein) is a well-established biomarker of systemic inflammation. Chronically mildly elevated CRP levels (0.3–1.0 mg/L) are associated in epidemiological studies with accelerated aging, cardiovascular disease, and reduced lifespan. However, CRP itself is not a direct cause—it reflects the inflammatory burden driven by factors such as visceral fat, smoking, poor sleep, or dysbiosis. Evidence comes mainly from observational studies and Mendelian randomization; randomized controlled trials directly linking CRP reduction to longevity are lacking. Interestingly, some longevity cohorts (e.g., centenarians) paradoxically show slightly elevated CRP, suggesting complex immune regulation. In practice, CRP measurement can serve as a risk indicator, but solely lowering CRP (e.g., via statins) is not a proven longevity intervention. Instead, lifestyle factors that promote inflammation should be addressed. Caveat: Single CRP values can be confounded by acute infections; repeated low-level measurements are more informative. Overall evidence is mixed—strong association but no proven causality for longevity.