What to watch with MTHFR and Sport?

The provided context lacks direct evidence on MTHFR and sport. Generally, MTHFR variants (e.g., C677T) affect folate metabolism and homocysteine levels. In athletes, elevated homocysteine may impair recovery and cardiovascular function. Adequate intake of active folate (5-MTHF), vitamin B12, and B6 is often suggested, but specific sports studies are absent. The evidence is mechanistic, based on general nutrigenetics. Caution: marketing often overstates MTHFR's role in performance. Without homocysteine blood tests and medical guidance, no sport-specific recommendations can be made. The cited sources (e.g., PMID:40786690 on B12 and testosterone) are not directly relevant to MTHFR and exercise.