Is AMH useful for fatigue?

AMH (anti-Müllerian hormone) is primarily a marker of ovarian reserve used in fertility assessment. There is no strong evidence that AMH is directly useful for evaluating fatigue. Fatigue has many causes—iron deficiency, thyroid dysfunction, poor sleep, stress, or chronic inflammation—which are better assessed with specific biomarkers. Low AMH may indicate perimenopause, which can be associated with fatigue, but this link is indirect and not causal. In men, AMH has virtually no role in fatigue workup. Therefore, measuring AMH for fatigue is not recommended unless there is a specific suspicion of premature ovarian insufficiency. The evidence is unclear, and the test should not be used as a general fatigue screening tool.