What do studies say about Menopause Check?

The rs4149056 C allele in the SLCO1B1 gene is associated with higher statin plasma levels and a moderately increased risk of myopathy (muscle pain), especially with simvastatin. In European populations, about 16% carry this allele. Importantly, the association is not deterministic – many carriers tolerate statins without issues. The evidence is human-strong for simvastatin myopathy, but weaker for other statins. A genetic test alone does not replace medical advice. Discuss with your doctor whether dose adjustment or switching to an alternative statin (e.g., rosuvastatin) is appropriate. Caveat: Consumer DNA tests are not clinical diagnostics and cannot fully capture drug interactions or individual risk profiles.