What role does FOXO3 play in Fruchtbarkeit?

FOXO3 is primarily known for its role in longevity, with the rs2802292 G allele associated with increased lifespan in GWAS. A direct role in fertility is not supported by the available evidence. Fertility is multifactorial, influenced by hormones, age, lifestyle, nutrition, and other genetic factors. FOXO3 may indirectly affect fertility through cellular stress resistance and aging, but the evidence is weak and not specific. MyBody-X DNA tests can detect such variants, but their clinical relevance for fertility remains unclear. Medical evaluation is essential for fertility concerns.