Skin aging in women is driven by a complex interplay of intrinsic (genetic) and extrinsic (UV exposure, lifestyle) factors. Genetic tests for skin aging (e.g., collagen, elastin, antioxidant genes) are mostly based on mechanistic or GWAS data with very small effect sizes. The predictive power of single SNPs is insufficient for individual recommendations, and many direct-to-consumer claims are exaggerated or unvalidated. Moreover, most studies are in European populations, limiting transferability to other ancestries. Risks of such tests include false reassurance (if 'good' genes are reported) or unnecessary worry (if 'bad' variants are found). Clinical relevance is low; lifestyle factors like sun protection, diet, and smoking cessation have far greater impact. Women should not rely on genetic tests but on evidence-based skincare and medical advice.
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