How are CYP2C19 and Sport related?

The relationship between CYP2C19 and sport is poorly supported by evidence. CYP2C19 is a drug-metabolizing enzyme involved in processing medications like proton pump inhibitors and clopidogrel. No strong studies link it directly to athletic performance, endurance, or muscle growth. Some research explores whether CYP2C19 variants affect caffeine metabolism, but CYP1A2 is the primary gene for that. Indirect effects via stomach acid regulation or supplement metabolism are theoretically possible but remain mechanistic speculation without clinical validation. For athletes, training, nutrition, and sleep are far more impactful. A DNA test for CYP2C19 does not provide actionable insights for sports optimization. Be cautious of marketing claims suggesting direct performance benefits.