What role does tTG IgA play in Darmgesundheit?

tTG IgA (antibodies against tissue transglutaminase) is a well-established serological marker for celiac disease, an autoimmune disorder triggered by gluten. Elevated tTG IgA indicates an immune attack on the intestinal lining, leading to villous atrophy, inflammation, and impaired nutrient absorption—directly compromising gut health. However, tTG IgA is not a general gut health marker; it is specific to celiac disease screening. A negative result does not rule out non-celiac gluten sensitivity or other gut issues. Evidence is human-strong, supported by decades of clinical validation and guidelines (e.g., ESPGHAN, ACG). Caveats: False negatives can occur in IgA-deficient individuals; total IgA should be measured concurrently. Positive results require confirmatory biopsy. Consumer DNA tests do not measure tTG IgA; this is a blood-based serology test ordered by physicians. For gut health optimization, tTG IgA is irrelevant unless celiac disease is suspected.