Risks and limits of MTHFR Alltag

MTHFR variants (especially C677T) are common and affect folate metabolism. Evidence shows a moderate association with elevated homocysteine levels, but no clear causal link to everyday complaints like fatigue or brain fog. Most direct-to-consumer tests overstate clinical relevance. An MTHFR finding alone does not justify specific treatment; a balanced diet rich in natural folate (kale, legumes) is beneficial for everyone. Caution is advised against unnecessary high-dose methylfolate supplements, which can cause side effects. Testing is evidence-based only in specific clinical contexts (e.g., elevated homocysteine, pregnancy history). In daily life, the benefit is usually below expectations.