FUT2 (fucosyltransferase 2) determines secretor status and influences gut microbiome composition by expressing H antigens on mucosal surfaces. Some research links the gut microbiome to sleep quality via neurotransmitter or short-chain fatty acid production. However, direct evidence for FUT2 variants affecting sleep is very weak. No robust GWAS or interventional studies demonstrate a clinically relevant role. Consumer DNA tests often overstate such variants by presenting mechanistic hypotheses as actionable insights. The evidence is mechanistic and speculative. Safety note: No specific sleep interventions based on FUT2 status are warranted. A balanced diet and good sleep hygiene are far more impactful than single genetic factors.
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