Progesterone is useful in menopause primarily for women with an intact uterus who are taking estrogen, as it protects the endometrium from hyperplasia and cancer. Combined hormone therapy effectively relieves vasomotor symptoms and sleep disturbances. However, large trials like the Women's Health Initiative show a small increase in breast cancer risk with long-term combined therapy. Progesterone alone is not recommended for menopausal symptoms due to limited efficacy. The decision should be individualized based on risk-benefit assessment and clinical guidance. The provided context does not contain specific information on progesterone for menopause, so this answer is based on established medical guidelines (e.g., NICE, DGGEF). Evidence level: human-strong (clinical trials).
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