What should I know about gewichtszunahme trotz kaloriendefizit?

Weight gain despite a calorie deficit is a common frustration. A possible genetic factor is the MC4R variant rs17782313 (C allele), which is associated with a slightly higher BMI in GWAS studies. However, the effect is small and not deterministic. Other causes – such as hypothyroidism, medication side effects, water retention, or inaccurate calorie tracking – are often more significant. Consumer DNA tests can detect such SNPs, but they offer suggestions, not diagnoses. The evidence for clinical actionability is weak (marketing/unclear). If you experience persistent weight gain despite a genuine deficit, consult a doctor to rule out medical conditions. Microbiome tests are also not yet validated for weight management. Focus on proven strategies: consistent tracking, whole foods, sleep, and stress management.