Myths vs facts: Zöliakie Test and Müdigkeit

The question of myths vs facts about celiac testing and fatigue is common. Fact: A positive celiac serology (tTG-IgA, EMA) followed by biopsy confirms celiac disease, an autoimmune condition triggered by gluten that can cause fatigue. Myth: A genetic test (HLA-DQ2/DQ8) alone does not diagnose celiac – it indicates predisposition (present in ~30 % of the population) but only ~1 % develop the disease. Many people with fatigue self-diagnose gluten sensitivity without celiac (non-celiac gluten sensitivity, NCGS), for which no validated biomarker exists; diagnosis is by exclusion. Direct-to-consumer DNA tests cannot confirm current fatigue due to celiac – blood markers and biopsy are required. Caution: self-imposed gluten-free diets without medical guidance may lead to nutrient deficiencies. Evidence: Celiac serology is well-established (human-strong), but fatigue is nonspecific. Sources: None provided in context.