How are HDL and Wechseljahre related?

HDL (high-density lipoprotein) and menopause (Wechseljahre) are linked via estrogen. Estrogen supports a favorable lipid profile, including higher HDL levels. During menopause, estrogen declines, often leading to lower HDL and higher LDL, increasing cardiovascular risk. However, the effect varies individually and is influenced by lifestyle (diet, exercise, smoking) and genetics. The evidence is strong (clinical studies, guidelines), but no specific sources are provided in the given context. Caveat: HDL's protective function (reverse cholesterol transport) may be impaired postmenopause. Raising HDL with drugs alone does not consistently reduce risk. Focus on overall lipid management and lifestyle rather than HDL in isolation.