How are CLOCK and Langlebigkeit related?

The relationship between CLOCK (a core circadian gene) and longevity is an active research area, but direct human evidence remains limited. Animal studies show that CLOCK mutations can lead to premature aging and metabolic dysfunction. In humans, certain CLOCK polymorphisms are associated with sleep disorders, metabolic syndrome, and possibly shorter telomere length—all factors that can influence lifespan. However, effect sizes are small and findings are inconsistent across populations. Direct causal evidence linking specific CLOCK variants to human longevity is lacking. Consumer DNA tests often overstate these associations. The evidence grade is human-moderate at best, with much still unknown. Practical takeaway: maintaining a consistent sleep-wake cycle and healthy circadian habits likely has a greater impact on healthspan than any single genetic variant.