Is tTG IgA useful for Langlebigkeit?

The tTG IgA test (tissue transglutaminase antibodies) is a well-validated diagnostic marker for celiac disease, an autoimmune condition that, if untreated, can cause chronic inflammation, nutrient malabsorption, and intestinal barrier dysfunction. These factors may negatively impact healthspan and longevity. However, tTG IgA is not a direct longevity test. In individuals without celiac disease or relevant symptoms (e.g., chronic fatigue, unexplained GI issues), the test provides no meaningful information about life expectancy or biological age. The evidence for its utility in longevity is indirect: early diagnosis and a gluten-free diet in celiac patients can prevent complications, potentially improving long-term health outcomes. For the general population without risk factors, the test is not recommended as a longevity biomarker. Caveat: a positive result requires clinical confirmation via duodenal biopsy. Do not use this test alone for longevity assessment.